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Stochastic Survival of the Densest and the Mitochondrial DNA Clonal Expansion in Ageing

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SPLW05 - Non-equilibrium explorations on the physics of life : remembering the biological physics of Tom McLeish

Clonal spread of DNA mutations is a fundamental phenomenon in both evolution and aging. High levels of mitochondrial DNA mutations are linked to muscle weakness in aging, which has a knock-on effect on overall health. For decades, scientists have asked how mitochondrial DNA harboring deleterious mutations can expand in skeletal muscle fibers. We provide evidence that this expansion could be driven by an unusual evolutionary mechanism, requiring only noise (stochasticity), a higher density of mutants, and a system with spatial structure. Critically, mutants need not replicate faster. This mechanism, that we have termed stochastic survival of the densest, can yield traveling waves of mutants even when the mutants are selectively eliminated, with potential applications in a range of evolutionary models.

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SS03 Hybrid (In-Person + Online). Google Meet: https://meet.google.com/yeu-pqce-rsn Webinar & FW11, Computer Laboratory, William Gates Building. Seminar room, Department of Biochemistry, Sanger Building

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