University of Cambridge > Talks.cam > Isaac Newton Institute Seminar Series > Protein allostery as an illustration of an ensemble approach towards understanding biological function

  Browse A-Z

Log in

University Account External (via Google)

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

Protein allostery as an illustration of an ensemble approach towards understanding biological function

Download to your calendar using vCal

If you have a question about this talk, please contact nobody.

SPLW05 - Non-equilibrium explorations on the physics of life : remembering the biological physics of Tom McLeish

We know from statistical physics that we need ensembles in order to extract microscopic understanding of collective phenomena. We have designed central-force spring networks to have a function inspired by protein allostery, in which a strain applied locally gives rise to a comparable local strain at a distant location. By analyzing an ensemble of networks designed to have the similar response, we find that the response is of a topological nature and can be characterized using persistent homology. Our analysis shows that allostery does not arise from discrete mechanisms but rather a continuum. Application of the persistent homology analysis to real proteins shows similar results.

This talk is part of the Isaac Newton Institute Seminar Series series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Average on weekdays: 9171.15374332 kWh Waterfront Conference Centre, Wyboston Lakes, Bedfordshire Webinar via Zoom) https://zoom.us/j/97493748184?pwd=Z1dZM2pxUk16QytPeU5NVWZ3bnZmdz09 Meeting ID: 974 9374 8184 Passcode: 404662

Other talks

Am I a Member? Auditing Private Machine Learning RNA-Mediated Regulation of Germinal Centre B-Cell Fitness: a tale of two DEAD-box RNA helicases TBC Necessary mechanisms for super AI and stopping hallucinations: The consistent reasoning paradox and the indeterminacy function Precarity and the economy of makeshifts: A novel argument from the census of England, 1851-1911 Title to be confirmed
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity