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The Francis Crick Lecture 2025 - The DNA Quadruplex Helix

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While DNA has been thought to exist primarily as a two-stranded double helix, there are alternative structures that can form. Particular G-rich sequences can fold into four-stranded structures called G-quadruplexes under physiological conditions. In this lecture, I will present our studies to explore the existence and function of G-quadruplexes structures in the DNA of cells and tissues in humans and in other species. The data suggests G-quadruplexes can play important roles in controlling transcription and cellular identity. Chemical biology approaches have been vital to help elucidate G-quadruplexes and provide insights into pathways for intervention that hold potential for therapeutics.

This talk is part of the MRC LMB Seminar Series series.

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