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LMB Seminar - Ribosome Upside Down: Co-translational Protein Biogenesis at the Tunnel Exit - In person only

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Our group aims to understand the cellular mechanisms underlying the production of functional proteins. This complex process requires an intricate interplay between the ribosome and a growing number of cellular factors that regulate translation and co-translational protein biogenesis. One of the key topics of our research, which combines structural, biochemical, and biophysical approaches, is the biogenesis of cytosolic and membrane proteins controlled by the nascent polypeptide–associated complex (NAC). I will present recent results that reveal how NAC coordinates the activity of a network of factors and enzymes at translating ribosomes to facilitate virtually all aspects of protein biogenesis, including nascent chain processing, modification, folding, and cellular localization such as targeting to the ER.

This talk is part of the MRC LMB Seminar Series series.

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Lecture Theatre, James Dyson Building, Department of Engineering See speaker's website for zoom link S3.05, Simon Sainsbury Centre, Cambridge Judge Business School

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