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Quantitative Biology Seminar

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If you have a question about this talk, please contact Kate Davenport .

Mapping the biochemical landscape of CO2 fixation The sequence-function landscape of a protein is the connection of genotype and phenotype at a molecular level. Although abstract, this concept has many real-world applications. Mapping and predicting this space would improve our basic science understanding of macromolecular function in the cell, clarify the role of genetic variation in causing disease, and lead to our ability to design new proteins with enhanced activity, stability, and specificity. The goal of our work is to develop experimental methods to systematically explore the mutational landscape of important enzymes such ribulose bisphosphate carboxylase / oxygenase, the principal CO2 -fixing enzyme in the biosphere. A related effort is to create new types of assays that yield robust measurements of biochemical parameters, rather than relative measurements which are typically measured out of convenience. Our work thus seeks to couple this data, mechanistic studies, and machine learning tools to develop state of the art methods for predicting and engineering protein function.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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