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LMB Seminar - Reconstructing biomolecular condensates for translation

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Cells use biomolecular condensates to organize and regulate when and where proteins are made. Among these, cytoplasmic RNA granules, including stress granules, P bodies, neuronal RNA granules, and germ granules, play a key role in storing and activating mRNAs, yet how individual components drive their function has been difficult to disentangle. By rebuilding germ granules from defined parts, we found that the DEAD -box RNA helicase Vasa and a simple RNA -binding scaffold are sufficient to recruit specific RNAs and trigger their translation. These findings reveal a minimal module for localized protein synthesis and show how synthetic biology can shed light on the principles of cellular organization.

This talk is part of the MRC LMB Seminar Series series.

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