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Poster Flash Talks Group B: Regulation of ultradian pulsatility and stress responses in the human HPA axis

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OOEW10 - Scoping meeting: Computation, modelling, and statistical analysis of physiological and clinical brain signals for real-time classification and prediction

The hypothalamic-pituitary-adrenal (HPA) axis is the endocrine system controlling dynamic responses to stressors. Mathematical modelling and experiments in rodents have shown that negative feedback loops underpin rhythmic activity within this axis, but a human equivalent model is lacking. This talk outlines a data-driven approach to calibrate a model of hormonal rhythms in the human HPA axis. The model is written in terms of Delay Differential Equations (DDEs) and predicts the conditions that lead to pulsatile secretion of cortisol and ACTH hormones with ultradian.

This talk is part of the Isaac Newton Institute Seminar Series series.

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FW11, William Gates Building. Zoom link: https://cl-cam-ac-uk.zoom.us/j/4361570789?pwd=Nkl2T3ZLaTZwRm05bzRTOUUxY3Q4QT09&from=addon in person & via zoom Pros of Voice over internet protocol

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