University of Cambridge > Talks.cam > Seminars at the Department of Biochemistry > Alkis Seraphim Lecture 2025: Mutate Everything! Mapping the energetic and allosteric structures of proteins at scale

Alkis Seraphim Lecture 2025: Mutate Everything! Mapping the energetic and allosteric structures of proteins at scale

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If you have a question about this talk, please contact Francis Neary .

Please Book Here: https://www.eventbrite.com/e/alkis-seraphim-lecture-2025-professor-ben-lehner-tickets-1869749433889?aff=TC

All welcome; followed by a drinks reception at 5.30pm in the Whale Café, University Museum of Zoology

Ben Lehner’s research is currently focussed on using massively parallel synthesis/selection/sequencing experiments and machine learning to quantify, understand and predict sequence-to-activity (especially the biophysical properties of macromolecules) at scale, including protein stability, aggregation, affinity, specificity, allostery, and mRNA splicing and regulation. Previous research has addressed foundational questions in genetics, including why genetically-identical individuals are not identical, how the physiology and environment of one generation alters subsequent generations, why mutations occur at different rates in different genes, and how mutations interact to alter the activities of molecules and the characteristics of individuals.

His research has been recognised by multiple prizes, including the Bettencourt Prize for Life Sciences, the Eppendorf Award, the Balfour Prize, and the EMBO Gold Medal. Ben is a Fellow of the Academy of Medical Sciences and a Fellow of the Royal Society.

This talk is part of the Seminars at the Department of Biochemistry series.

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