Alkis Seraphim Lecture 2025: Mutate Everything! Mapping the energetic and allosteric structures of proteins at scale
- 👤 Speaker: Professor Ben Lehner, Head of Generative and Synthetic Genomics at the Wellcome Sanger Institute 🔗 Website
- 📅 Date & Time: Thursday 04 December 2025, 16:30 - 17:30
- 📍 Venue: Babbage Lecture Theatre, New Museums Site, Pembroke Street, Cambridge CB2 3QF
Abstract
Please Book Here: https://www.eventbrite.com/e/alkis-seraphim-lecture-2025-professor-ben-lehner-tickets-1869749433889?aff=TC
All welcome; followed by a drinks reception at 5.30pm in the Whale Café, University Museum of Zoology
Ben Lehner’s research is currently focussed on using massively parallel synthesis/selection/sequencing experiments and machine learning to quantify, understand and predict sequence-to-activity (especially the biophysical properties of macromolecules) at scale, including protein stability, aggregation, affinity, specificity, allostery, and mRNA splicing and regulation. Previous research has addressed foundational questions in genetics, including why genetically-identical individuals are not identical, how the physiology and environment of one generation alters subsequent generations, why mutations occur at different rates in different genes, and how mutations interact to alter the activities of molecules and the characteristics of individuals.
His research has been recognised by multiple prizes, including the Bettencourt Prize for Life Sciences, the Eppendorf Award, the Balfour Prize, and the EMBO Gold Medal. Ben is a Fellow of the Academy of Medical Sciences and a Fellow of the Royal Society.
Series This talk is part of the Seminars at the Department of Biochemistry series.
Included in Lists
- Babbage Lecture Theatre, New Museums Site, Pembroke Street, Cambridge CB2 3QF
- Cambridge Infectious Diseases
- ndk22's list
- PMRFPS's
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Professor Ben Lehner, Head of Generative and Synthetic Genomics at the Wellcome Sanger Institute 
Thursday 04 December 2025, 16:30-17:30