Information and Noise in Cell-Specific Gene Expression

Add to your list(s) Download to your calendar using vCal

• Prof. Edo Kussell, Department of Biology, New York University, USA
• Thursday 30 September 2010, 16:15-17:00
• MRC LMB: Cell Biology Seminar Room (Level 4, Room 4014).

If you have a question about this talk, please contact M. Madan Babu.

Advances in biological understanding are increasingly reliant on quantitative modeling and theory that capture critical aspects of biological phenomena. In developmental biology and in the study of cellular dynamics, quantitative data are available on the activity of genes in individual cells or cell-type samples.  But how should we formalize the intuitive concept of cell-type specificity? This talk presents measurements of cell-type specificity based on the amount of information that a gene?s level of expression provides about the identity of the cell. The approach is applied to global cell-type specific data available in the Arabidopisis root and the mouse brain, revealing the modular structure of multicellular transcriptomes involved in tissue patterning.  Applications to biomarker discovery and treatment-specific data sets will also be discussed.

This talk is part of the mbm30's list series.

This talk is included in these lists:

• MRC LMB: Cell Biology Seminar Room (Level 4, Room 4014)

Note that ex-directory lists are not shown.