Imaging prions: the intracellular site of conversion and the mechanism of intercellular spreading

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• Dr Chiara Zurzolo, Unité de Trafic Membranaire et Pathogénèse, Institut Pasteur, Paris.
• Thursday 07 April 2011, 12:00-13:00
• Brain Repair Centre, Forvie Site, Robinson Way.

If you have a question about this talk, please contact Shannon Tinley-Browne.

Prion diseases are fatal, neurodegenerative disorders in human and animals, characterized by the accumulation of an abnormally folded isoform of the cellular prion protein (PrPC), denoted PrPSc. The mechanism of PrPC to PrPSc conversion is not known but it comprises changes in PrPC structure and biochemical properties. It is also not known where the conversion process occurs inside the cells, and which trafficking pathways allow the encounter and the conversion of PrPC into PrPSc. Furthermore, it is still a mystery how PrPSc invades the CNS from the periphery and which mechanisms allow prions to spread from cell to cell. We are currently analysing both the mechanisms of prion conversion and of prions spreading and I will focus my talk on two recent findings of the lab: 1) prion conversion occurs/involves the endosomal recycling compartment (Marjianovic et al, PloS Path 2009), and 2) tunnelling nanotubes are involved in the transfer PrPSc between different cells (Gousset et al, NCB 2009 ).

This talk is part of the BRC Seminar Series series.

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