University of Cambridge > Talks.cam > BRC Seminar Series > Imaging prions: the intracellular site of conversion and the mechanism of intercellular spreading

  Browse A-Z

Log in

University Account External (via Google)

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹ️ Information

Imaging prions: the intracellular site of conversion and the mechanism of intercellular spreading

Download to your calendar using vCal

If you have a question about this talk, please contact Shannon Tinley-Browne .

Prion diseases are fatal, neurodegenerative disorders in human and animals, characterized by the accumulation of an abnormally folded isoform of the cellular prion protein (PrPC), denoted PrPSc. The mechanism of PrPC to PrPSc conversion is not known but it comprises changes in PrPC structure and biochemical properties. It is also not known where the conversion process occurs inside the cells, and which trafficking pathways allow the encounter and the conversion of PrPC into PrPSc. Furthermore, it is still a mystery how PrPSc invades the CNS from the periphery and which mechanisms allow prions to spread from cell to cell. We are currently analysing both the mechanisms of prion conversion and of prions spreading and I will focus my talk on two recent findings of the lab: 1) prion conversion occurs/involves the endosomal recycling compartment (Marjianovic et al, PloS Path 2009), and 2) tunnelling nanotubes are involved in the transfer PrPSc between different cells (Gousset et al, NCB 2009 ).

This talk is part of the BRC Seminar Series series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Lenguaje integral Hybrid: Seminar room, SPRI & Teams - email organiser for details https://youtu.be/bkG_fgrkV5E

Other talks

Title TBC On convective penetration of a buoyant plume into a stably stratified layer Machine Politics? Computers and AI in the History of Political Thought Rothschild Public Lecture | Forty years of causal inference: Report of a great-grandfather Group Work The search for a new population of strong gravitational lenses with JWST
 

© 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity