Electrochemical detection in nanochannels: a new single-molecule technique

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• Prof. Searge J. G. Lemay, University of Twente, The Netherlands
• Friday 18 March 2011, 14:00-15:00
• Pippard Lecture Theatre, Cavendish Laboratory.

If you have a question about this talk, please contact Erika Eiser.

We have developed a new single-molecule detection technique based on electrochemical detection at pairs of metal electrodes imbedded in a nanochannel. The target molecules are electrochemically active and free to diffuse in the 50 nm high, water-filled channel separating the electrodes. As a direct consequence of the tiny volumes involved, equilibrium statistical fluctuations in the number of molecules present inside the devices can be observed with the “naked eye” as electrical noise. This mesoscopic effect is the electrochemical equivalent of Fluorescence Correlation Spectroscopy (FCS), and serves as a microscopic probe of the adsorption dynamics of the target molecules. Recently, we have managed to further boost sensitivity so as to reach the ultimate limit: the electrical detection of individual small molecules in solution.

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