University of Cambridge > Talks.cam > MRC LMB Seminar Series > Mechanisms for the Selective Degradation of Ubiquitinated Proteins by the 26S Proteasome

  Browse A-Z

Log in

University Account External (via Google)

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

Mechanisms for the Selective Degradation of Ubiquitinated Proteins by the 26S Proteasome

Download to your calendar using vCal

If you have a question about this talk, please contact Scientific Meetings Co-ordinator .

The 26S Proteasome is the major site for protein degradation in eukaryotic cells and selectively digests proteins marked for degradation by attachment of a ubiquitin chain. Recent studies indicate multiple ATP -dependent steps in this process and clarify how certain types of ubiquitinated proteins become tightly bound and how deubiquitination, ATP hydrolysis, and proteolysis are coupled. In this process, the six proteasomal AAA AT Pase subunits function cooperatively to drive protein unfolding translocation, and opening the gate for substrate-entry into the 20S proteolytic core. Prof Goldberg will also discuss how proteasome function is impaired in certain neurodegenerative disease and the development of the proteasome inhibitors, now widely used as scientific reagents and in the treatment of hematologic cancers.

This talk is part of the MRC LMB Seminar Series series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

MR 9 CRASSH and CRP, Alison Richard Building, West Road, University of Cambridge Hybrid: Seminar room, SPRI & Zoom - email organiser for details

Other talks

Professor Philip Rosenstiel, W3 Professor of Clinical Molecular Biology, Director, Institute of Clinical Molecular Biology (IKMB), Kiel University Title to be confirmed The search for a new population of strong gravitational lenses with JWST Title to be confirmed How Far Can Good Go Without God? The Limits of a Naturalistic Ethic Title to be confirmed
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity