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Glutamine Metabolism and mTOR Signaling in Cell Growth Regulation

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If you have a question about this talk, please contact Dr Ireena Dutta.

Glutaminolysis is the double de-amination of glutamine to produce alpha-ketoglutarate, a process upregulated in cancer cells. Our investigations showed that glutaminolysis activates mTORC1 and cell growth through the activation of prolyl hydroxylases. This results suggest a mechanism to explain glutamine addiction in cancer cells beyond the energetic demand, namely that glutamine sustains cell growth via the activation of mTORC1.

This talk is part of the MRC Cancer Unit Seminars series.

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