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Dr Julian C Knight, University of Oxford
Wednesday 17 October 2012, 12:30-13:30
Insights into regulatory genetic variation involving the human MHC
- đ¤ Speaker: Dr Julian C Knight, University of Oxford
- đ Date & Time: Wednesday 17 October 2012, 12:30 - 13:30
- đ Venue: Lecture Theatre, Department of Pathology, Tennis Court Road
Abstract
The human Major Histocompatibility Complex (MHC) on chromosome 6p21 is a remarkable region of the genome, showing extraordinary genetic diversity and genetic associations with disease.
In my talk I will describe how functional genomic approaches may be used to resolve regulatory variants and provide new insights into the relationship between genetic variation and disease susceptibility. I will discuss allele-specific analysis of specific loci and global approaches using a custom MHC array to interrogate extended MHC haplotypes implicated in autoimmune disease.
I will also present data based on expression quantitative trait mapping in primary peripheral blood leukocytes which has defined trans associations involving the MHC , together with resolution of context specific expression associated variants for specific MHC genes.
Series This talk is part of the Immunology in Pathology series.
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