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Proteins, Crystals and mechanisms

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If you have a question about this talk, please contact Sven Friedemann .

Structural biology provides a fundamental molecular understanding of biological processes. One of the most common ways to determine a protein structure is through its crystallisation and subsequent exposure to X-rays. Within this talk I shall highlight how one goes from a protein in solution to a crystal and finally to a three-dimensional structure. Along this way I shall point out some of the most common pitfalls that we face, almost seemingly on a daily basis. Finally, I will demonstrate with a specific example form our current research how structures provide a rational for enzyme mechanism and a more global implication in cellular signalling. This provides potential pharmacological targets for treating human diseases.

This talk is part of the Darwin College Science Seminars series.

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Department of Computer Science Faculty of Education, 184 Hills Road, Cambridge, CB2 8PQ, Donald MacIntyre Building Rooms 8 & 9, Faculty of Asian & Middle Eastern Studies

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