Direct Selection for Antibodies that Control Cell Fates from Intracellular Combinatorial Antibody Libraries

Add to your list(s) Download to your calendar using vCal

• Professor Richard Lerner, The Scripps Research Institute, USA
• Wednesday 05 June 2013, 12:00-13:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

In this talk we will describe the use of combinatorial antibody libraries to endow cells with new binding energy landscapes for the purpose of regulating their phenotypes. Antibodies that are expressed in cells infected with a lentiviral combinatorial antibody library are selected directly for function rather than only for binding. Many different agonist antibodies were selected using this method including TPO , EPO, G-CSF, integrin, and neurogenesis phenocopies.. The most powerful format is an autocrine based selection system.

This talk is part of the MRC LMB Seminar Series series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• Cambridge Immunology
• Centre for Health Leadership and Enterprise
• Liam
• Life Sciences
• Life Sciences
• ME Seminar
• MRC LMB Seminar Series
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• cri
• my_list
• other talks
• rc781

Note that ex-directory lists are not shown.