Abstract

Development of genomic analysis through a personalized medicine program at Gustave Roussy

Ludovic Lacroix, Fabrice Andre, Jean-Charles Soria

The Gustave Roussy comprehensive molecular screening program is being developed to complement our hospital’s clinical trials strategy. The main molecular triage trials are shown in table 1. This whole initiative is supported by a variety of funding sources including: specific state grants, collaborative programs with biotech or pharmaceutical companies as well as philanthropic funding. The MSN (Melanoma, Small cell and Nonsmall cell lung cancer) trial was launched in 2009. It is a mono-centric molecular screening trial for tumor samples (either archived or newly collected) from patients with lung cancer and melanomas [Planchard]. The SAFIR01 trial, which was launched in 2011 for patients with metastatic breast cancer and is now closed to recruitment, required dedicated freshly frozen tumor biopsy samples. SAFIR01 was sponsored by UNICANCER , the former French Federation of Cancer Centers and funded by INCa [André ASCO ]. The upcoming SAFIR02 trials will use NGS (70 genes), CGH and treatment arms according to molecular screening results for patients with metastatic breast and non-small cell lung cancer. MOSCATO (MOlecular Screening for Cancer Treatment Optimization), was launched in 2012. It is a mono-centric molecular triage trial for early phase I candidates and combines CGH array and sequencing of a gene panel performed on fresh tumor biopsy samples [Hollebecque]. The WINTHER Trial was launched in 2013. It is an international non-randomized molecular triage study undertaken by the WIN consortium, requiring dedicated freshly frozen tumor biopsy samples and normal matched tissue used to screen for mutations, translocations and copy number variations (CNV) by NGS , completed with RNA and microRNA exploration for tumors without actionable drug targets [Kurzrock]. Data and design regarding all these trials will be presented.

References

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