Kinetics and Pathways in Self-Assembly: Light Scattering and Theoretical Studies on Human Papillomavirus Capsids

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• Professor David Wu, Chemical Engineering Department, Colorado School of Mines
• Friday 09 June 2006, 14:15-15:15
• IRC in Superconductivity Seminar Room, Cavendish Laboratory.

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Viral self-assembly is an archetype of self-assembly from a few relatively simple subunits into a complex functional structure. Although extraordinary progress has been made in determining the structure of icosahedral viruses, relatively little is known about the mechanisms of assembly. Such knowledge is important not only for biological understanding of viruses, and potential therapeutic exploitation, but also for general insights into the control of self-assembly. We have measured capsid growth by multi-angle laser light scattering and identified points of kinetic control within a single-pathway model due to Zlotnick. Using stochastic simulations of model assembly systems, we have demonstrated that off-pathway assembly and error-correction can qualitatively change the rate and fidelity of self-assembly.

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