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Genome wide characterization of Foxa1/2 binding sites reveals multiple mechanisms for regulating neuronal specification and differentiation in midbrain dopamine cells.

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If you have a question about this talk, please contact Shannon Tinley-Browne .

The transcription factors Foxa1 and Foxa2 promote the specification of midbrain dopaminergic neurons. To better understand their functions, we characterized the Foxa1/2 cis-regulatory network by chromatin immunoprecipitation followed by high-throughput sequencing of dopamine neurons using in vitro and in vivo mouse models. The results highlight important mechanisms critical to midbrain dopamine neuron development.

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