Imaging embryonic morphogenesis

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• Dr Richard Adams (Department of Physiology Development and Neuroscience)
• Friday 17 November 2006, 14:15-14:45
• Kaetsu Centre, New Hall.

If you have a question about this talk, please contact Duncan Simpson.

The Activity of Living Matter

Embryos undergo substantial cellular rearrangements during development. These movements shape the form of the embryo in a process called morphogenesis. Our long-term goal is to understand how these mechanical processes are enacted and controlled in space and time. To help us see how morphogenesis is achieved, we can use time-lapse microscopy to collect volumetric records of developing embryos. The resultant movies contain a wealth of information about the changes in form of tissues as well as the behaviours of the many individual cells that make them up. We are developing methods that allow us to track and analyse these events so that we can measure the dynamics of morphogenesis. We would like to understand how cell behaviours collectively reshape tissues, therefore we use these analyses to link deformations seen at these two levels. Using these tools we can assay the effects of the manipulation of molecular pathways that we believe to be controlling and organising cell behaviours and thus morphogenesis.

This talk is part of the Physics of Living Matter PLM6 series.

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