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Tetrahydrobiopterin - Role in Ether Lipid Metabolism of Macrophages

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If you have a question about this talk, please contact Dr. Markus A Keller .

Tetrahydrobiopterin is an essential cofactor a set of metabolic reactions. It is well known for its role in the four aromatic amino acid hydroxylases (PAH) and three nitric oxide synthases (NOS). Recently we identified a gene coding for the integral membrane protein alkylglycerol monooxygenase, which catalyses a third destinct class of tetrahydrobiopterin-dependent reactions. The cytokine-regulation of the enzyme in macrophages provides a first glimpse on potential biological roles of this novel gene.

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Newnham College MCR (directions available from Porter's Lodge) Meeting Rooms 1&2, MRC Epidemiology Unit, Level 3, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ The Umney Theatre, Robinson College, Grange Road, CB3 9AN

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