Perutz Lecture 2016

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• Ron Vale, University of California
• Thursday 02 June 2016, 11:00-12:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

The T cell immune response is initiated when the major histocompatibility complex (MHC) protein on the surface of an antigen-presenting cell (APC) interacts with the T-cell receptor (TCR) on a T lymphocyte. We are attempting to understand the initial events in signal propagation using a reductionist approach. In cells, we have replaced the normal T cell receptor with a “chimeric” receptor that can be engineered to study how variations in ligand binding affinity are transduced into intracellular signals. We also have been reconstituting biochemical reactions in the signalling pathway. With ~12 purified proteins or protein complexes, we have been able to reconstitute the signalling pathway from TCR phosphorylation to the nucleation of actin polymerization on planar lipid bilayers. This work illustrates how biochemical reconstitution combined with light microscopy can be used to dissect the biochemical network that underlies the T cell signalling cascade.

This talk is part of the MRC LMB Seminar Series series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• Cambridge Immunology
• Centre for Health Leadership and Enterprise
• Liam
• Life Sciences
• Life Sciences
• ME Seminar
• MRC LMB Seminar Series
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• cri
• my_list
• other talks
• rc781

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