Engineering riboswitches to enable rational control of transgene expression

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• Christopher Finch, 1st yr grad
• Friday 01 May 2015, 11:30-12:00
• Sainsbury Laboratory.

If you have a question about this talk, please contact Helen Scott.

Microalgae are of particular interest for biotechnology because they fix carbon from the atmosphere, and can therefore sustainably produce fossil fuel substitutes, as well as high-value compounds such as antioxidants and pharmaceuticals. Genetic modification can increase the productivity of microalgae, but currently only limited tools exist to control the expression of added genes. Our lab has explored the use of endogenous gene regulatory elements to modulate transgene expression in the model microalga Chlamydomonas reinhardtii. My research focuses on riboswitches, mRNA motifs that regulate gene expression in response to binding a specific ligand. Here, I show the versatility of native thiamine-responsive riboswitches and describe my efforts to expand the regulatory properties of the THI4 riboswitch.

This talk is part of the Plant Sciences Departmental Seminars series.

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