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Silicon Tether Motif in C-H Functionalization Reactions

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We have developed a set of new transition metal-catalyzed C-H activation methodologies employing a silicon-tether motif. These methods feature: (a) use of silyl group as a tether between a substrate and a reagent, thus transforming intermolecular reaction into intramolecular reaction; (b) employment of a silicon-tethered directing group, which is traceless or easily convertable into valuable functionalities; (c) use of silyl-tethered hydrosilane reagent; and (d) introduction of new N/Si-chelation concept that allows for a remote activation of aliphatic C-H bonds.

The scope of these transformations will be demonstrated and the mechanisms will be discussed.

This talk is part of the Synthetic Chemistry Research Interest Group series.

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