University of Cambridge > Talks.cam > MRC LMB Seminar Series > Milstein Lecture-Phosphoinositide 3-Kinase and Cancer Metabolism

  Browse A-Z

Log in

University Account External (via Google)

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

Milstein Lecture-Phosphoinositide 3-Kinase and Cancer Metabolism

Download to your calendar using vCal

If you have a question about this talk, please contact Scientific Meetings Co-ordinator .

In general cancer cells produce higher levels of reactive oxygen species (ROS) than normal cells due to increased rates of metabolism and defective mitochondria. In order to survive under conditions of high ROS , cancer cells typically turn on pathways for generating NADPH and glutathione to bring ROS levels back to homeostasis. Activating mutations in PIK3CA or loss of PTEN or activating mutations in KRAS can stimulate glucose uptake and metabolism and pathways for generating NADPH and glutathione to suppress ROS . A detailed understanding of the biochemical mechanisms by which cancer cells suppress excess ROS may suggest new therapies for inducing synthetic lethality in tumors that evolve in specific mutational backgrounds. Our research using human cancer cell lines and genetically engineered mouse models suggests new approaches for killing cancer cells by targeting metabolic pathways for ROS suppression that allow cancer cells to survive.

This talk is part of the MRC LMB Seminar Series series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

FW11 Seminar Room (William Gates Building) LR3A, Department of Engineering Drum Building, Madingley Rise Site, West Cambridge

Other talks

Washing machines and their rare components: lessons from kidney patients The Magic of Magnetism Tea and Coffee Break Talk TBC Group Presentation 5 Clonal haematopoiesis, early detection and pre-leukemia to leukemia development
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity