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MODIFYING THE GLIAL SCAR TO PROMOTE REPAIR AND REGENERATION AFTER SPINAL CORD INJURY

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If you have a question about this talk, please contact Shannon Tinley-Browne .

The glial scar that forms after spinal cord injury is a complex assembly of diverse cellular elements and extracellular matrix molecules that is considered a physical and biochemical barrier to successful axon regeneration. I will discuss several different molecular and cellular approaches to modifying the formation and properties of the glial scar and the effects of these manipulations on axonal regrowth and functional recovery after experimental injury to the thoracic spinal cord. These results demonstrate that the glial scar is not an insurmountable barrier to recovery. The approaches we have developed may have therapeutic potential.

This talk is part of the BRC Seminar Series series.

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