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Crick 2016 Lecture-DNA Sequence and the Epigenome Entwined

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Epigenome refers to the panoply of chemical modifications borne by DNA and its associated proteins that locally affect genome function. Patterns of epigenomic marking are often thought to reflect external constraints including disease and the environment, but DNA sequence is also a potential influence. Evidence that sequence-specific DNA binding proteins mould and interpret the epigenome will be discussed. Experimental support for the notion that gross features of DNA sequence are read as signals to influence the epigenome and gene activity will also be presented.

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