University of Cambridge > Talks.cam > BSS Formal Seminars > Conformational Spread: The Propagation of Allosteric States in Large Multiprotein Complexes

  Browse A-Z

Log in

University Account External (via Google)

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

Conformational Spread: The Propagation of Allosteric States in Large Multiprotein Complexes

Download to your calendar using vCal

  • UserProf. Dennis Bray, Emeritus Professor, Department of Physiology, Development and Neuroscience, University of Cambridge Speaker website
  • ClockFriday 26 February 2016, 14:00-15:00
  • HousePippard Lecture Theater.

If you have a question about this talk, please contact Dr. Hernandez-Ainsa .

The phenomenon of allostery is conventionally described for small symmetrical oligomeric proteins such as haemoglobin. However, our work on the bacterial chemotaxis pathway leads us to the view that conformational changes can also propagate through extended lattices of protein molecules. We have explored the statistical mechanics of idealized linear and two-dimensional arrays of allosteric proteins and shown that, as in the analogous Ising models, arrays of closely packed units can show large-scale integrated behavior. Applied to the chemotaxis system, conformational spread can explain the switching characteristics of the flagellar motor and the high amplification of signals at the chemotactic receptors. Our analysis applies to a variety of other systems such as muscle ryanodine receptors, actin filaments, and offers a more realistic view of the transitions of haemoglobin molecules. We suggest that conformational spread could provide the basis of a condensed state circuitry in a living cell, able to integrate biochemical and biophysical events over hundreds of protein molecules

This talk is part of the BSS Formal Seminars series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

New Seminar Rooms, Strangeways Research Laboratory CIKC Talks Law Faculty, Sidgwick Site

Other talks

Afternoon Break Title to be confirmed BSU Seminar: "Response Adaptivity Across Clinical Trials In Portfolios of Biomedical Innovations" Afternoon Break Group Work Title to be confirmed
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity