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Field cancerization and recurrence in head and neck squamous cell carcinoma

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SDBW01 - Opening workshop

Co-authors: Kevin Leder (University of Minnesota), Marc Ryser (Duke University), Walter Lee (Duke University)

The accumulation and spatial spread of mutations during carcinogenesis leads to the production of premalignant 'fields' in many epithelial cancers. I will discuss a spatial stochastic model of this process, based on the biased voter model, and analysis of the extent and geometry of these fields. We apply this model to head and neck squamous cell carcinoma and use it to understand population-level incidence and recurrence patterns.

This talk is part of the Isaac Newton Institute Seminar Series series.

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