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The role of cell competition in tumour growth

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  • UserSaskia Suijkerbuijk (Pidini lab, Gurdon Institute/ Kops lab, Utrecht)
  • ClockWednesday 16 November 2016, 17:30-19:30
  • HouseGurdon Institute Tea Room.

If you have a question about this talk, please contact Clara Sidor.

In tissues, growth and survival of cells depends on relative fitness levels. The strongest cells are selected while the less fit cells are eliminated through a process known as cell competition. We have recently shown that in the adult Drosophila posterior midgut growing tumors use cell competition to kill surrounding cells and cause host tissue attrition. Inhibition of cell competition prevents adenoma growth, indicating that it is an essential driver of tumor growth in this tissue. This talk will highlight our findings in the fly model and our current advances in the development of mammalian models for cell competition.

This talk is part of the Cambridge Fly Meetings series.

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