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Structure and Function of TIFA - A New Player in Immunity and Cancer

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TRAF -interacting protein with FHA domain (TIFA) was first reported by M. Kanamori et al. to activate NF-κB, and it was recently shown to be a key player in the NF-κB-driven innate immunity. In this seminar I will discuss our recent reports on the mechanism and structural basis for the function of TIFA in the activation of NF-κB, as well as unpublished results suggesting that TIFA functionally mediates the Aurora A-driven NF-κB survival pathway in acute myeloid leukemia (AML), and that TIFA mediates innate immune response through assembly of NLRP3 inflammasome.

This talk is part of the Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery series.

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