Synthesis and Analysis of Nanobody Sequence and Structure Data

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• Laura Mitchell (University of Cambridge)
• Friday 28 October 2016, 12:00-12:20
• Unilever Lecture Theatre, Department of Chemistry.

If you have a question about this talk, please contact Lisa Masters.

1st Year PhD Report

Nanobodies are a class of antigen-binding protein derived from heavy-chain antibodies in camels, llamas and alpacas. They achieve high affinity binding specificities equivalent to antibodies; despite comprising only a single 15 kDa variable domain. Their restricted size greatly reduces the possible sequence space available for encoding specificity, making the question underpinning the sequence-specificity relationship more tractable. In this talk I present sequence and structural analysis of the largest set of nanobody:antigen co-crystal structures compiled to date, which has revealed surprising findings relating to the conservation of nanobody framework regions, the composition of nanobody sequence-variable loops and the distribution of specificity-determining residues.

This talk is part of the Extra Theoretical Chemistry Seminars series.

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