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Dr Marcel den Hoed, Department of Medical Sciences, Molecular Epidemiology and SciLifeLab, Uppsala University. 
Friday 14 December 2018, 12:30-13:30
Modelling cardiovascular and metabolic disease using transgenic zebrafish
- 👤 Speaker: Dr Marcel den Hoed, Department of Medical Sciences, Molecular Epidemiology and SciLifeLab, Uppsala University. 🔗 Website
- 📅 Date & Time: Friday 14 December 2018, 12:30 - 13:30
- 📍 Venue: Meeting rooms, Level 4 Institute of Metabolic Sciences, Addenbrooke’s Treatment Centre (ATC)
Abstract
Genome-wide association studies identified hundreds of loci that are associated with cardiometabolic diseases and risk factors. For most loci the causal genes remain unknown. My group developed experimental pipelines that facilitate image-based genetic screens in zebrafish larvae by using: 1) the zebrafish’ well-annotated genome; 2) CRISPR -Cas9 based mutagenesis; 3) fluorescent transgenes and dyes; 4) automated positioning and imaging technologies; 5) custom-written image quantification pipelines. Results from dietary, drug and genetic screens confirm that zebrafish larvae represent an opportunity to identify causal genes for cardiometabolic diseases and risk factors, and increase our understanding of disease aetiology.
Series This talk is part of the IMS Epidemiology Seminars series.
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