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Toll Receptors

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TLRs are single pass transmembrane receptors and are activated by a variety of stimuli derived from microbes. The mechanism of signal transduction involves stimulus induced dimerization of two receptor chains. Dimerization appears to involve concerted protein conformational changes and cooperativity which generate a specific cytoplasmic protein scaffold that supports downstream signalling events. I will present recent data about he molecular nature of this signalling process and evidence for complex crosstalk with other signalling pathways such as those of PKC .

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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