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The transcriptional battle between phage and host in the Pseudomonas phage infected cell

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  • UserMr Bob G Blasdel, KU Leuven, Leuven, Belgium
  • ClockWednesday 18 January 2017, 08:30-09:00
  • HouseOnline.

If you have a question about this talk, please contact Ilana Spilka .

Detailed knowledge of phage lifecycles, have been limited to few model bacteriophages mostly infecting Escherichia coli as well as the results of increasingly antiquated methods. However, next-generation techniques now make it possible to explore how phage affect host transcription and metabolism, now re-sparked by modern therapeutic and biotechnological potential, as well as to ask deeper more comprehensive questions. By performing RNA -Seq on synchronously infected cells we are able to compare host transcript data for early, middle and late transcription with six fundamentally different lytic phages: N4likevirus, Phikzlikevirus, Yualikevirus, Pbunalikevirus, Phikmvlikevirus, and novel F7-like viruses infecting P. aeruginosa PAO1 .

This talk is part of the Bacteriophage 2017 series.

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