Abstract

It has been recognised that biofilm formation is one of the main problems associated with chronic wounds and persistent infections causing delayed healing. The current therapies to treat bacterial infection in the wound rely mostly on the systemic administration of antibiotics, but the related major concerns are the risk of toxicity during treatment and insufficiently low local drug levels in the wound. Traditional topical formulations require frequent application and thus are ineffective in the presence of wound exudate or biofilm. Therefore, there is a need to find better treatment options for infected wounds. Antibacterial drug-loaded electrospun fibers have several characteristics that favour their use in infected wound care. The talk will shortly cover the reasons for chronic wound infection and then step-by-step overview will be presented about the development of electrospun matrices/dressings and their advantages for the local treatment of infected wounds. This knowledge is important for the development of novel multicomponent antimicrobial wound dressings intended for successful wound healing.