Abstract

Speaker Background:

The aim of the laboratory is to unveil fundamental biological mechanisms and understand how these become perturbed during diseases, most prominently cancer, with the ambition that our findings may contribute to the development of clinical tools. We focus mainly on various classes of non-coding RNAs, such as microRNAs, snoRNAs, tRNAs and lncRNAs. In addition, we study RNA binding proteins and RNA modifications. Special focus areas include the regulation of central tumor suppressor pathways and autophagy.

Recent papers:

· Damas, N.D. et al. (2016). SNHG5 promotes colorectal cancer cell survival by counteracting STAU1 -mediated mRNA destabilization. Nature Communications, doi:10.1038/ncomms13875.

· Montes, M., et al. (2015). The lncRNA MIR31HG regulates p16INK4a expression to modulate senescence. Nature Communications. DOI : 10.1038/ncomms7967.

· Fog, C.K., et al. (2015). Loss of PRDM11 promotes B cell lymphomagenesis. Blood. 125: 1272-1281.

· Frankel, L.B., et al. (2014). A non-conserved miRNA regulates lysosomal function and impacts human lysosomal storage disorders. Nature Communications. DOI : 10.1038/ncomms6840.

· Gingold, H., Tehler, D, et al. (2014). A dual program for translation regulation in cellular proliferation and differentiation. Cell 158:1281-1292.

Homepage: http://www.bric.ku.dk/Research/Lund_Group/