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Julia Muenzener: Viral subversion of host cell membrane trafficking

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Enveloped viruses acquire their membrane coat from host cells and rely on cellular machinery to facilitate envelopment and egress of virus progeny. During my PhD, I examined egress-related interactions between host cell factors and proteins of two viruses, hepatitis D virus (HDV) and herpes simplex virus 1 (HSV-1). Using structural and biochemical techniques, I investigated the interaction between the large antigen of HDV and the trafficking protein clathrin. Only few interactions between HSV -1 and cellular proteins promoting viral egress are known. Using unbiased screening, I identified novel binding partners of the HSV -1 protein UL56 .

This talk is part of the Pathology Valedictory Seminars series.

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Average on weekdays: 9108.60955882 kWh Department of Engineering - Lecture Theater 6 Webinar & FW11, Computer Laboratory, William Gates Building.

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