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SUMMARY:Conformational and oligomeric rearrangements control intercellular
  signalling - Dr. Bert Janssen\, Utrecht University
DTSTART:20180320T100000Z
DTEND:20180320T110000Z
UID:TALK102994@talks.cam.ac.uk
CONTACT:Robert Jones
DESCRIPTION:Intercellular communication\, orchestrated by cell-surface exp
 ressed proteins\, is a fundamental aspect of the formation\, function and 
 pathology of all tissues and organs. Protein structure\, interaction and c
 onformational change determine signalling and adhesion events. Using two t
 arget systems with central roles in the formation and maintenance of our n
 ervous system\; transmembrane receptors Myelin associated glycoprotein (MA
 G) and Sortilin\, we show how interactions and conformational changes on t
 he cell surface and between cells underlie the molecular mechanisms of sig
 nal transduction and adhesion.
LOCATION:MRC LMB: Sanger Seminar Room 3A180
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