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SUMMARY:Development and characterization of diffuse intrinsic pontine glio
 ma mouse models generated by brainstem in utero electroporation - Dr Tim P
 hoenix\, University of Cincinnati and Cincinnati Children’s Hospital Med
 ical Centre
DTSTART:20180504T110000Z
DTEND:20180504T120000Z
UID:TALK105451@talks.cam.ac.uk
CONTACT:Helen Anderson
DESCRIPTION:Tim Phoenix\, PhD\, conducted his graduate training in develop
 mental neurobiology with Dr Sally Temple at Albany Medical College. His po
 stdoctoral training with Prof Richard Gilbertson at St. Jude Children’s 
 Research Hospital focused on defining tumour microenvironment heterogeneit
 y\, identifying difference in blood-brain barrier function between medullo
 blastoma subgroups. In the summer of 2016 he joined the faculty at the Uni
 versity of Cincinnati and Cincinnati Children’s Hospital Medical Centre.
  The Phoenix lab is focused on advancing our understanding of paediatric b
 rain tumour diversity\, and developing new tools and therapies to improve 
 patient outcome. A main area of interest in the lab is to understand how b
 rain tumour genetic heterogeneity alters the tumour microenvironment. By b
 uilding new animal models that reflect distinct genetic variants and molec
 ular subgroups\, we are investigating effects on tumour-vascular interacti
 ons (angiogenesis\, blood-brain barrier maintenance\, vascular-niche)\, an
 d their role in brain tumour pathogenesis.
LOCATION:CRUK Cambridge Institute Room 215
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