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SUMMARY:The evaluation of lyssavirus cross-neutralising antibody responses
  using lentiviral pseudotypes. - Dr Edward Wright\, University College\, L
 ondon
DTSTART:20080311T110000Z
DTEND:20080311T120000Z
UID:TALK11024@talks.cam.ac.uk
CONTACT:Prof. Jonathan Heeney
DESCRIPTION:We have analysed cross-neutralisation between rabies virus\, C
 VS-11\, and two European bat lyssaviruses\, EBLV-1 and -2\, using lentivir
 al pseudotypes as antigen vectors.  This development of a robust microassa
 y that can be performed outside of high containment facilities will aid on
 -going surveillance and vaccine studies.  Tests on blinded sera from rabie
 s virus vaccine recipients revealed that the CVS-11 pseudotype assay had 1
 00% concordance with the current “gold standard” fluorescent antibody 
 virus neutralisation test\, and neutralising titres strongly correlated.  
 Pseudotypes incorporating the G-protein from different lyssavirus genotype
 s were used to analyse antibody titres with respect to G-protein identity.
   The results revealed that the relative neutralisation titres correlated 
 broadly with the degree of G-protein diversity.
LOCATION:Lecture Theatre 2
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