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SUMMARY:Adrian Seminar - "Probing computations in neural circuits using si
 ngle-neuron perturbations" - Chris Harvey\, Harvard Medical School
DTSTART:20181015T153000Z
DTEND:20181015T170000Z
UID:TALK110563@talks.cam.ac.uk
CONTACT:Lyn Dakin
DESCRIPTION:A major goal in neuroscience is to understand how local neuron
 al populations transform the information they receive as inputs. Toward th
 is goal\, we have developed a new method in which we use single-neuron per
 turbations combined with large-scale\, cellular-resolution population acti
 vity measurements to map the causal\, functional connectivity among neuron
 s with characterized tuning. We call this method influence mapping – a m
 easure of how one neuron’s spiking affects spiking in its neighbors. We 
 have discovered a like-suppresses-like motif in layer 2/3 of mouse visual 
 cortex that reduces redundancy in population activity and may assist infer
 ence of the features underlying sensory input. I will also outline how we 
 are applying influence mapping to the study of computations for flexible s
 ensorimotor decision-making.\n.\n\n
LOCATION:The Hodgkin Huxley Seminar Room\, Department of Physiology Develo
 pment and Neuroscience
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