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SUMMARY:CUNanoSoc Presents: Nanophotonics - Speaker to be confirmed
DTSTART:20181018T180000Z
DTEND:20181018T193000Z
UID:TALK112231@talks.cam.ac.uk
CONTACT:James Macdonald
DESCRIPTION:Vibrating Single-molecule Coupled to Plasmonic Nanocavity\nDr 
 Rohit Chikkaraddy\nNanophotonics Centre\n\n\nIn this talk\, I will discuss
  our recent success in confining optical fields to atomic scales allowing 
 to visualise vibrational and electronic dynamics of a single-molecule [1\,
 2]. Optical confinement is achieved via plasmonic coupling between metalli
 c nano-components\, generating strongly red-shifted resonances with intens
 e local field amplification at the nanoscale. This allows us to directly '
 see' motion of individual atoms\, vibrations of single-molecules as well a
 s excitations in monolayer semiconductors [3\,4]. I will in particular sho
 w our recent work exploring the coupling of tightly confined optical field
 s to precisely positioned and oriented single-molecules using DNA origami 
 techniques\, supramolecular guest-host assembly and self-assembled monolay
 ers\, which also now accesses the regime of molecular strong-coupling and 
 enhanced emission[5]. Further\, I will show how these can produce sensing 
 systems which are relevant for widespread applications.\n\n \n\nReferences
 :\n\n[1] Nature 535\, 127 (2016)\; Single-molecule strong coupling at room
  temperature in plasmonic nanocavities.\n[2] Science 354\, 726 (2016)\; Si
 ngle-molecule optomechanics in picocavities.\n[3] ACS Photonics\, 4\, 469 
 (2017)\; How Ultranarrow Gap Symmetries Control Plasmonic Nanocavity Modes
 : From Cubes to Spheres in the Nanoparticle-on-Mirror.\n[4] Nature Comm\, 
 8\, 1296 (2017)\; Strong-coupling of WSe2 in ultra-compact plasmonic nanoc
 avities at room temperature.\n[5] Nano Letters\, 18\, 405 (2018)\; Mapping
  Nanoscale Hotspots with Single-Molecule Emitters Assembled into Plasmonic
  Nanocavities Using DNA Origami.\n\n\n\n\nWafer-scale integration of nano-
 \, and microfluidics with two-photon lithography\nOliver Vanderpooten\nDep
 artment of Chemical Engineering and Biotechnology\n\n\nThe misfolding of p
 roteins inside neuronal cells is known to be linked to neurodegenerative d
 iseases such as Alzheimer's and Parkinson disease. [1] Microfluidics produ
 ced via soft lithography have become a powerful tool to characterize these
  protein aggregates “in vitro” under controlled conditions and within 
 confined spaces. [2] The nanofluidic regime with its new promising transpo
 rt phenomena [3]\, cannot be easily integrated into this technique by biol
 ogical laboratories without access to clean room facilities. Therefore\, w
 e use 2-photon lithography - which can be best described as “3D printing
  on the nanoscale” – to accelerate lab-on-chip prototyping and to prod
 uce nanochannel molds with heights down to 55 nm without the need for any 
 clean room machinery. We characterized the method’s printing capabilitie
 s with atomic force microscopy (AFM)\, scanning electron microscopy (SEM) 
 and show nanofluidic master wafer fabrication from the micron to the sub 1
 00 nm regime. STORM super-resolution-microscopy images of diffusing Rhodam
 ine 6G dye verify a successful integration of 300 nm wide nanochannels int
 o a microfluidic chip. By combining UV-lithography with 2-photon direct la
 ser writing we developed a procedure to make rapid wafer-scale nanofluidic
  prototyping possible.\n\nKeywords: Protein misfolding diseases\; Nanofilt
 ration\; Nanofabrication\; Lab-on-chip\; Super resolution microscopy\;\n\n
 [1] Clemens F. Kaminski\, Gabriele S. Kaminski Schierle\, Probing amyloid 
 protein aggregation with optical superresolution methods: from the test tu
 be to models of disease\, Neurophoton. 3(4)\, 041807 (2016).\n[2] Knowles\
 , T. P. J. et al. Observation of spatial propagation of amyloid assembly f
 rom single nuclei. Proc. Natl. Acad. Sci. 108\, 14746–14751\, DOI: 10.10
 73/pnas.1105555108 (2011).\n[3] Bocquet\, L. & Charlaix\, E. Nanofluidics\
 , from bulk to interfaces. Chem. Soc. Rev. 39\, 1073–1095\, DOI: 10.1039
 /B909366B (2010).
LOCATION:Pfizer Lecture Theatre\, Department of Chemistry
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