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SUMMARY:Regulation of Cell-Type Specific Regulatory Programs in the Sea An
 emone Nematostella vectensis - Dr Heather Marlow\, Institut Pasteur\, Pari
 s
DTSTART:20181114T130000Z
DTEND:20181114T140000Z
UID:TALK112372@talks.cam.ac.uk
CONTACT:Kate Criswell
DESCRIPTION:Specification of cell fate identity during development of mult
 icellular organisms is a fundamental process underlying differentiation. T
 he organism must integrate genomically encoded information at the level of
  the gene regulatory network in order to direct the differentiation of dis
 tinct cell-type specific developmental programs. We utilize the sea anemon
 e Nematostella vectensis as a model for cell fate specification and study 
 this process within the context of embryonic and regenerative neurogenesis
 . Using single cell sequencing as a read-out for cell identity\, we have g
 enerated a complete atlas of sea anemone cell types across the development
 al time course as well as during the regenerative process.  Using this app
 roach\, we find a diversity of cell types in the nervous system with over 
 30 distinct cell states represented. We utilize transgenic reporter constr
 ucts driving cell-type specific expression via neural promoters which have
  been identified in our single cell studies to label and track cell popula
 tions over embryogenesis and regeneration. By utilizing these novel report
 er lines to sort specific neural sub-populations\, we are able to perform 
 chromatin accessibility studies using ATAC-seq to identify and link regula
 tory elements to the expression of key genes in the network. In this way\,
  we are assembling gene regulatory networks for developmental and regenera
 tive neurogenesis using a candidate-gene independent approach. This approa
 ch is particularly suited to the investigation of non-Bilaterian neuron sp
 ecification as it allows for the discovery of lineage-specific innovations
  in cell type specification.
LOCATION:Part II Lecture Theatre\, Department of Zoology
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