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SUMMARY:On the structure-function uncertainties of proteins - Prof. Monika
  Fuxreiter\, Department of Biochemistry and Molecular Biology\, University
  of Debrecen\, Hungary
DTSTART:20181018T100000Z
DTEND:20181018T110000Z
UID:TALK113062@talks.cam.ac.uk
CONTACT:Gabriella Heller
DESCRIPTION:Advances in structural and cell biology – in parallel with l
 aboratory evolution – indicate complex relationships between sequences\,
  structures and functions of proteins\, which may not be described by dete
 rministic principles. Adaptive transitions in conformational landscapes si
 multaneously affect ambiguous as well as context-specific interactions\, t
 he functional outcomes of which are hard to predict. To describe dynamical
  behaviour of proteins under stochastic cellular conditions\, I propose to
  include multiple functionally relevant states and their uncertainties in 
 structure-function relationships. In analogy to artificially intelligent (
 AI) systems\, the fuzzy set theory offers a mathematical framework to desc
 ribe the appropriate sequence\, structure and function sets and their unce
 rtainties\; whereas their connections could be treated by a fuzzy inferenc
 e model. I discuss a series of results supporting the fuzzy model\, from e
 nzymatic catalysis to dynamic protein complexes and higher-order structure
 s. I will also present various approaches/formalisms how uncertainty could
  be estimated from sequence and forecast cellular behaviours.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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