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SUMMARY:Non invasive detection of tissue specific cell death via methylati
 on patterns of circulating DNA - Prof Yuval Dor from The Hebrew University
 -Hadassah Medical School
DTSTART:20181119T163000Z
DTEND:20181119T173000Z
UID:TALK114091@talks.cam.ac.uk
CONTACT:72001
DESCRIPTION:Cell-free circulating DNA (cfDNA)\, released from dying cells\
 , is emerging as a diagnostic tool for monitoring cancer dynamics and graf
 t failure. We developed a method of detecting tissue-specific cell death i
 n humans\, based on tissue-specific methylation patterns of DNA circulatin
 g in plasma. We interrogated tissue-specific methylome datasets to identif
 y cell type-specific DNA methylation signatures\, and established a method
  to detect these in mixed DNA samples and in cfDNA isolated from plasma. U
 sing this new type of biomarker it is possible to detect the presence of c
 fDNA fragments derived from multiple tissues in healthy individuals and in
  pathologies including cancer\, myocardial infarction\, sepsis\, neurodege
 neration and more. In the long run we envision this approach opening a min
 imally-invasive window for monitoring and diagnosis of a broad spectrum of
  human pathologies\, as well as better understanding of normal tissue dyna
 mics.
LOCATION:CRUK CI Lecture Theatre (Room 001)
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