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SUMMARY:LMB Seminar Series Milstein Lecture - Intracellular Membrane Conta
 ct Sites\, Lipid Dynamics and Neurodegeneration - Pietro De Camilli Depart
 ments of Neuroscience and Cell Biology\, Howard Hughes Medical Institute\,
  Kavli Institute for Neuroscince\, Yale University School of Medicine
DTSTART:20190305T160000Z
DTEND:20190305T170000Z
UID:TALK116656@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:A defining characteristic of eukaryotic cells is the presence 
 of intracellular membranes. The most abundant endomembrane system is the e
 ndoplasmic reticulum (ER)\, which participates in a multiplicity of functi
 ons\, including protein and lipid synthesis\, a variety of metabolic react
 ions and intracellular signaling.  The ER extends in all regions of neuron
 s\, including the most distal compartments of dendrites and axons.  While 
 membranes of the ER are functionally connected to all membranes of the sec
 retory and endocytic pathways via vesicular transport\, they only physical
 ly fuse with each other and with vesicles involved in retrograde transport
  from the Golgi complex. However\, close appositions between the ER and ot
 her membranes mediated by tethering proteins play important roles in cell 
 physiology\, and their dysfunctions result in disease\, including neurodeg
 eneration. In my talk I will discuss the properties\, regulation and funct
 ions of proteins that tether the ER to other membranes with emphasis on pr
 oteins that mediate lipid exchange between bilayers independently of vesic
 ular transport.  I will focus in particular on VPS13A and VPS13C\, a new c
 lass of lipid transport proteins whose mutations result in neuroacanthocyt
 osis (a Huntington’s disease-like condition) and Parkinson’s disease r
 espectively.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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