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SUMMARY:Investigating the propagation and spreading of protein aggregates 
 in C. elegans - Carmen Nussbaum-Krammer\, Zentrum für Molekulare Biologi
 e der Universität Heidelberg (ZMBH)
DTSTART:20190320T103000Z
DTEND:20190320T113000Z
UID:TALK118978@talks.cam.ac.uk
CONTACT:Gabriella Heller
DESCRIPTION:Many neurodegenerative diseases such as Alzheimer’s disease 
 or Parkinson’s disease are associated with the gradual accumulation and 
 characteristic spreading of pathological proteins. Mechanisms underlying t
 he prion-like propagation of protein aggregates remain\, however\, largely
  elusive. I will present our ongoing work using the nematode Caenorhabditi
 s elegans as a model system to discover and examine cellular pathways and 
 factors that influence the propagation and intercellular spreading of dise
 ase-associated proteins (e.g.\, α-Synuclein) in metazoans. A better under
 standing of these mechanisms might eventually identify new druggable targe
 ts for the treatment of neurodegenerative diseases.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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