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SUMMARY:Escaping Mendel’s laws: Epigenetic insights from the sulfurea pa
 ramutation in Solanum Lycopersicum. - Claudia dos Santos Martinho\, Baulco
 mbe group
DTSTART:20190530T120000Z
DTEND:20190530T123000Z
UID:TALK123751@talks.cam.ac.uk
CONTACT:Ronelle Roth
DESCRIPTION:Gene silencing events can distort meiotically heritable epigen
 etic responses by altering gene expression without involving changes in DN
 A sequences. Paramutation is such a gene silencing process\, found across 
 kingdoms\, that involves the trans silencing of an active (paramutable) al
 lele caused by a silent (paramutagenic) allele. The silent-state of the pa
 ramutable allele is heritable and this allele can become paramutagenic in 
 subsequent generations thereby altering Mendelian patterns of inheritance.
  The establishment and maintenance of paramutation has been explained by m
 odels invoking small RNA (sRNA) mediated silencing and/or chromatin struct
 ure modifications that facilitate the transfer of the epigenetic mark.\n\n
 This talk will address a particular case of paramutation\, the sulfurea (s
 ulf) allele\, which is a silent and paramutagenic epigenetic variant of a 
 tomato (Solanum lycopersicum cv Lukullus) gene involved in chlorophyll syn
 thesis. Using genetic analysis\, sRNA sequencing\, chromatin conformation 
 capture (HiC/4C) in chlorotic leave tissues\, I will discuss the molecular
  mechanism underlying paramutation.\n
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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